Peripheral artery disease (PAD) is a serious medical condition in which stenotic or blocked arteries result from plaque accumulation. The leg arteries are most commonly affected causing diminished blood flow to the feet. Atherosclerotic plaque is made of heterogeneous material that often contains a combination of soft fibrous plaque and hard, calcified plaque.

There are over 200 million people worldwide who are living with PAD1 resulting in over 700,000 interventional procedures in the US and Europe each year2. PAD affects between 3%-7% of the entire population, and up to 1 in 5 people over the age of 753. In addition, the problem is growing at an alarming rate of 7% per year4. In the leg arteries, the symptoms include claudication, or pain when walking, worsening to pain at rest.